Benefits:
-increased serotonin production
-reduces anxiety
-reduced brain fog
-increases energy levels
-improved cognition and memory
-neuroprotective for alzheimer patients
-improved mitochondrial function
-antiaging properties
-reduces wrinkles and increases skin firmness
-reduces inflammation
-anti-parisitic agent
 
Originally formulated in 1876, Methylene blue was used as anti-malarial agent and as a blue dye. It can inhibit soluble guanyl cyclase, scavenge the free radical nitric oxide (NO), and modulate the NO-cyclic guanosine monophosphate (cGMP) signaling pathway. 
 
By improving mitochondrial efficiency and supporting the electron transport chain, methylene blue directly enhances the overall performance of your mitochondria. This contributes to better energy production, cellular repair, and resilience, laying the foundation for improved physical and cognitive performance.
 
Methylene blue has potential serotonergic benefits by acting as a monoamine oxidase (MAO) inhibitor, particularly targeting MAO-A, which results in increased serotonin levels in the brain. However, be advised that combining this product with traditional SSRIs can lead to serotonin syndrome.
 
Methylene blue also reduces oxidative stress in the brain. This chemical process is implicated in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. More specifically, methylene blue acts as an electron carrier in the electron transport chain, wherein it inhibits complexes I and III to promote respiration.
 
According to the “free radicals theory of aging”, cell and tissue aging are a result of free radicals’ attacks. In human cells, reactive oxygen species (ROS) are mainly produced in mitochondria, while aging, declines in mitochondrial mass, respiration capacity, and respiration efficiency were observed in different tissues. Dysfunctional mitochondria lead to decreased ATP production and increased ROS production, which would further damage mitochondria. This vicious cycle leads to severe cellular damages and accelerates the aging process. Methylene blue’s antioxidative properties mainly improve mitochondrial function and break the ROS–mitochondrial damage cycle, which makes it a great candidate as an anti-aging drug.
 
Methylene blue also has profound benefits for your skin. Environmental factors, especially UV radiation, cause the accumulation of ROS on skin, leading to DNA damage, impaired ETC, decreased collagen synthesis, and increased collagen breakdown. As a potent antioxidant, MB can effectively combat ROS and presents the accelerated aging induced by ROS. In addition, MB can stimulate fibroblast proliferation, thereby promoting wound healing. Furthermore, MB is a broad-spectrum UV chemical blocker (Figure created with BioRender.com, 10 October 2021). Together, MB renders three levels of protection to human skin, from blocking UV irradiation, mitigating the cellular oxidative damages, to stimulating skin proliferation and wound healing.